Could Zinc be a Botox® Booster?


The effects of Botox®  and other botulinum toxin injections such as Dysport, and Myobloc are estimated to last about 3 – 4 months for the average patient.  However, in some cases it is observed that the effects can last for a longer or shorter period of time.  It has been observed that the results can even differ from treatment to treatment in the same patient without any real explanation as to why.  Dr. Charles Soparkar, an Oculoplastic surgeon from Texas noticed this in his practice and began to investigate.  He realized there may be a link between Botox® and Zinc.

Dr. Soparkar’s study was recently released indicating the mineral Zinc as a “Botox® Booster.” The study by Dr. Charles Soparkar and his team indicates that when patients in the study took Zinc Citrate 50 mg in combination with the enzyme phytase 3000U for four days prior to the injection, they saw not only an increase in the effectiveness of neurotoxins (Botox® Cosmetic, Dysport, Myobloc) but also in the longevity.

Neurotoxins such as Botox® Cosmetic, Dysport and Myobloc are used to temporarily smooth facial lines and to decrease spastic muscle movement.  Botulinum toxin is thought to require a certain baseline zinc level in the body because each molecule of the botulinum toxin must bind to a molecule of zinc to be effective. Phytase is an enzyme which increases the body’s ability to absorb zinc and is therefore thought to increase the effectiveness and duration of Botox® and the like. In this study, 92% of the patients who took both zinc citrate and phytase had on average a 30% increase in the duration of the Botox® injection and 84% of patients reported an improved effect when compared to Botox® with Zinc only or a placebo only. One thing to consider in this study is that it appears that over half of the patients were over the age of seventy. Could that explain the increased effectiveness of Botox® in this study since Zinc levels are often lower in patients of this age group?

This study was carried out by researchers from Baylor College of Medicine, MD Anderson Cancer Center, the Methodist Hospital and Weill Cornell University.   The patients in this study were being treated for blepharospasms, hemifacial spasms and facial wrinkles.

While this study may offer answers to why Botox® lasts longer in some patients, keep in mind that the author of this study has a patent pending for the use of zinc and phytase for enhancing the efficacy of botulinum toxins injections, which presents a conflict of interest for the author of the study. His pending patent is for a prescription supplement called Zytate, manufactured by OCUSOCT Inc.  Each prescription costs about $80.00 for a five day regimen.

If you find the effectiveness of your Botox® treatments to vary it could be worth testing your zinc levels. I hope the author of this study is on to something as I am sure both Dr. Castillo and our patients would be very excited if we would offer a option for more effective, longer lasting Botox®.  However, I would like to see the results of other large clinical trials on this topic done by other researchers before drawing a final conclusion.


Yours Truly,

Can we now offer a "Botox® Booster" to our patients for a longer lasting, more effective result?

Anti-Aging With Grace…


Roxanne Hammond, RMA
Skincare and Laser Specialist
G. D. Castillo, M.D.

800-252-7123 (within IL)
217-359-7508 Savoy (Champaign-Urbana)




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